Effect of toxin-g from Tityus serrulatus scorpion venom on gastric emptying in rats

The effect of toxin-gamma from Tityus serrulatus scorpion venom on the gastric emptying of liquids was studied in 176 young adult male Wistar rats (2-3 months of age) divided into subgroups of 8 animals each. Toxin-gamma was injected i.v. at doses of 25, 37.5, 50 or 100 micrograms/kg and the effect...

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Bibliographic Details
Published in:Brazilian journal of medical and biological research 1999-04, Vol.32 (4), p.431-434
Main Authors: Bucaretchi, F, Vinagre, A M, Chavéz-Olórtegui, C, Collares, E F
Format: Article
Language:eng ; por
Subjects:
Animals
BIOLOGY
Gastric Emptying - drug effects
Male
MEDICINE, RESEARCH & EXPERIMENTAL
Rats
Rats, Wistar
Scorpion Venoms - toxicity
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Summary:The effect of toxin-gamma from Tityus serrulatus scorpion venom on the gastric emptying of liquids was studied in 176 young adult male Wistar rats (2-3 months of age) divided into subgroups of 8 animals each. Toxin-gamma was injected i.v. at doses of 25, 37.5, 50 or 100 micrograms/kg and the effect on gastric emptying was assessed 30 min and 8 h later. A time-course study was also performed by injecting 50 micrograms of toxin-gamma/kg and measuring the effect on gastric emptying at times 0.25, 0.5, 1, 2, 4, 8, 24 and 48 h post-venom. Each envenomed animal was paired with its saline control and all received a saline test meal solution containing phenol red (60 micrograms/ml) as a marker. Ten minutes after administering the test meal by gavage the animals were sacrificed and gastric retention was determined by measuring the residual marker concentration of the test meal. A significant delay in gastric emptying, at 30 min and 8 h post-venom, was observed only after 50 and 100 micrograms of toxin-gamma/kg compared to control values. The responses to these two doses were significantly different after 8 h post-venom. Toxin-gamma (50 micrograms/kg) significantly delayed the gastric emptying of liquids at all times studied, with a peak response at 4 h after toxin administration compared to control values. These results indicate that the i.v. injection of toxin-gamma may induce a rapid, intense and sustained inhibition of gastric emptying 0.25 to 48 h after envenomation.
ISSN:0100-879X
1414-431X
1414-431X
0100-879X
DOI:10.1590/S0100-879X1999000400009