Common findings on head computed tomography in neonates with confirmed congenital Zika syndrome

To describe head computed tomography (CT) findings in neonates with congenital Zika virus infection confirmed in cerebrospinal fluid. This was a study of 16 newborn infants who exhibited abnormal head CT findings during an outbreak of Zika virus infection. Those infants had the following features: b...

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Published in:Radiologia brasileira 2018-11, Vol.51 (6), p.366-371
Main Authors: Petribu, Natacha Calheiros de Lima, Fernandes, Andrezza Christine Vieira, Abath, Marília de Brito, Araújo, Luziany Carvalho, de Queiroz, Felipe Reis Silva, Araújo, Janniê de Miranda, de Carvalho, Glauber Barbosa, van der Linden, Vanessa
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Language:eng ; por
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RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
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Summary:To describe head computed tomography (CT) findings in neonates with congenital Zika virus infection confirmed in cerebrospinal fluid. This was a study of 16 newborn infants who exhibited abnormal head CT findings during an outbreak of Zika virus infection. Those infants had the following features: brain imaging suggestive of congenital infection; brain calcifications and negative results on tests for other main infectious causes of primary microcephaly, namely toxoplasmosis, cytomegalovirus, rubella, and HIV; positivity for Zika virus on IgM antibody capture enzyme-linked immunosorbent assay in cerebrospinal fluid. Decreased brain volume was observed in 13 (81.2%) of the infants. All of the infants showed cortico-subcortical calcifications, mainly located in the frontal lobe. In 15 neonates (93.7%), ventriculomegaly was observed. Colpocephaly was a common finding, being observed in 10 patients (62.5%). A prominent occipital bone was identified in 9 patients (56.2%). Our study proves that Zika virus infection can cause congenital brain damage, with or without microcephaly. Some predominant head CT findings in neonates with congenital Zika virus infection, although not pathognomonic, are strongly suggestive of a pattern.
ISSN:0100-3984
1678-7099
1678-7099
DOI:10.1590/0100-3984.2017.0119