Drug resistance of M. Tuberculosis isolated from patients with HIV infection seen at an AIDS Reference Center in São Paulo, Brazil

M. tuberculosis-positive cultures were obtained from 228 patients seen in our service and drug sensitivity assays were carried out from January 1992 to December 1994. A survey of the medical records of these patients showed resistance to one or more drugs in 47 (20.6%), 25 of whom (10.9%), who repor...

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Bibliographic Details
Published in:Revista do Instituto de Medicina Tropical de São Paulo 1996, Vol.38 (1), p.15-21, Article 15
Main Authors: Pinto, W P, Hadad, D J, Palhares, M C, Ferrazoli, L, Telles, M A, Ueki, S Y, Santos, M T, Placco, A L, Sauaia, N, Palaci, M
Format: Article
Language:eng ; por
Subjects:
Acquired Immunodeficiency Syndrome - drug therapy
Acquired Immunodeficiency Syndrome - epidemiology
Adolescent
Adult
AIDS/HIV
Antitubercular Agents - therapeutic use
Brazil - epidemiology
Causality
Chi-Square Distribution
Cohort Studies
Drug Resistance, Microbial
Female
Follow-Up Studies
HIV Infections - drug therapy
HIV Infections - epidemiology
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Multivariate Analysis
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - isolation & purification
Survival Rate
TROPICAL MEDICINE
Tuberculosis - drug therapy
Tuberculosis - epidemiology
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - epidemiology
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Summary:M. tuberculosis-positive cultures were obtained from 228 patients seen in our service and drug sensitivity assays were carried out from January 1992 to December 1994. A survey of the medical records of these patients showed resistance to one or more drugs in 47 (20.6%), 25 of whom (10.9%), who reported previous treatment, were considered to have acquired resistance. Among the antecedents investigated, only previous treatment and alcoholism were the factors independently associated with the occurrence of resistance. The survival of patients with resistant strains was lower than that of patients attacked by non-resistant M. tuberculosis. We conclude that in the present series M. tuberculosis resistance to tuberculostatic agents was predominantly of the acquired type.
ISSN:0036-4665
1678-9946
1678-9946
0036-4665
DOI:10.1590/S0036-46651996000100004