Definition and diagnosis of small fiber neuropathy: consensus from the Peripheral Neuropathy Scientific Department of the Brazilian Academy of Neurology

The aim of this study was to describe the results of a Brazilian Consensus on Small Fiber Neuropathy (SFN). Fifteen neurologists (members of the Brazilian Academy of Neurology) reviewed a preliminary draft. Eleven panelists got together in the city of Fortaleza to discuss and finish the text for the...

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Published in:Arquivos de neuro-psiquiatria 2018-03, Vol.76 (3), p.200-208
Main Authors: Gondim, Francisco de Assis Aquino, Barreira, Amilton Antunes, Claudino, Rinaldo, Cruz, Márcia Waddington, Cunha, Francisco Marcos Bezerra da, Freitas, Marcos Raimundo Gomes de, França, Jr, Marcondes Cavalcante, Gonçalves, Marcus Vinícius Magno, Marques, Jr, Wilson, Nascimento, Osvaldo José Moreira, Oliveira, Acary Souza Bulle, Pereira, Raquel Campos, Pupe, Camila, Rotta, Francisco Tellechea, Schestatsky, Pedro
Format: Article
Language:eng ; por
Subjects:
Autonomic nervous system
Electromyography
fibras nervosas amielínicas
neuropatia de pequenas fibras
NEUROSCIENCES
Pain
Peripheral neuropathy
Pruritus
PSYCHIATRY
Sensory neurons
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Summary:The aim of this study was to describe the results of a Brazilian Consensus on Small Fiber Neuropathy (SFN). Fifteen neurologists (members of the Brazilian Academy of Neurology) reviewed a preliminary draft. Eleven panelists got together in the city of Fortaleza to discuss and finish the text for the manuscript submission. Small fiber neuropathy can be defined as a subtype of neuropathy characterized by selective involvement of unmyelinated or thinly myelinated sensory fibers. Its clinical picture includes both negative and positive manifestations: sensory (pain/dysesthesias/pruritus) or combined sensory and autonomic complaints, associated with an almost entirely normal neurological examination. Standard electromyography is normal. A growing list of medical conditions is associated with SFN. The classification of SFN may also serve as a useful terminology to uncover minor discrepancies in the normal values from different neurophysiology laboratories. Several techniques may disclose sensory and/or autonomic impairment. Further studies are necessary to refine these techniques and develop specific therapies.
ISSN:0004-282X
1678-4227
1678-4227
DOI:10.1590/0004-282x20180015