Antiviral mechanism change of poly(styrene sulfonate) through gold nanoparticle coating

Viruses are pathogens capable of causing serious global health problems and therefore the development of interventions against them is of paramount importance. One strategy towards designing broad-spectrum antivirals is through the mimicking of sulfonated glycopolymers on the cell surface so that th...

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Bibliographic Details
Published in:Polymer chemistry 2024-03, Vol.15 (1), p.945-951
Main Authors: Bhebhe, Lorraine M, Kim, Jungyeon, Jones, Luke M, Super, Elana H, Jones, Samuel T
Format: Article
Language:English
Subjects:
Glycopolymers
Gold
Nanoparticles
Polymers
Polystyrene resins
Public health
Styrenes
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Summary:Viruses are pathogens capable of causing serious global health problems and therefore the development of interventions against them is of paramount importance. One strategy towards designing broad-spectrum antivirals is through the mimicking of sulfonated glycopolymers on the cell surface so that the virion/cell interaction is inhibited by the antiviral material. A number of natural and synthetic polymers have been investigated, however, most show a virustatic mechanism, which is reversible and non-destructive. Herein we present a facile route to virucidal materials by attaching a previously known virustatic polymer, poly(styrene sulfonate), onto gold nanoparticles. We show that it is possible to alter the polymer's mode of action whilst maintaining its low IC 50 by changing the macromolecular architecture. Viruses are capable of causing serious global health problems. The development of interventions against them is of paramount importance. Here we achieve the sought-after virucidal mechanism using poly(styrene sulfonate) coated gold nanoparticles.
ISSN:1759-9954
1759-9962
DOI:10.1039/d3py01217d