Recent advances in mixing-induced nanoprecipitation: from creating complex nanostructures to emerging applications beyond biomedicine

Mixing-induced nanoprecipitation (MINP) is an efficient, controllable, scalable, versatile, and cost-effective technique for the preparation of nanoparticles. In addition to the formulation of drugs, MINP has attracted tremendous interest in other fields. In this review, we highlight recent advances...

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Bibliographic Details
Published in:Nanoscale 2023-02, Vol.15 (8), p.3594-369
Main Authors: Chen, Tianyou, Peng, Yan, Qiu, Meishuang, Yi, Changfeng, Xu, Zushun
Format: Article
Language:English
Subjects:
Controllability
Emulsions
Inks
Nanomaterials
Nanoparticles
Nanostructure
Phase separation
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Summary:Mixing-induced nanoprecipitation (MINP) is an efficient, controllable, scalable, versatile, and cost-effective technique for the preparation of nanoparticles. In addition to the formulation of drugs, MINP has attracted tremendous interest in other fields. In this review, we highlight recent advances in the preparation of nanoparticles with complex nanostructures via MINP and their emerging applications beyond biomedicine. First, the mechanisms of nanoprecipitation and four mixing approaches for MINP are briefly discussed. Next, three strategies for the preparation of nanoparticles with complex nanostructures including sequential nanoprecipitation, controlling phase separation, and incorporating inorganic nanoparticles, are summarized. Then, emerging applications including the engineering of catalytic nanomaterials, environmentally friendly photovoltaic inks, colloidal surfactants for the preparation of Pickering emulsions, and green templates for the synthesis of nanomaterials, are reviewed. Furthermore, we discuss the structure-function relationships to gain more insight into design principles for the development of functional nanoparticles via MINP. Finally, the remaining issues and future applications are discussed. This review will stimulate the development of nanoparticles with complex nanostructures and their broader applications beyond biomedicine. Nanoparticles with complex nanostructures created by mixing-induced nanoprecipitation and their emerging applications beyond biomedicine are reviewed.
ISSN:2040-3364
2040-3372
DOI:10.1039/d3nr00280b