pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation

Amphotericin B incorporating 2,2′-bipyridine (bpy-AmB) forms a membrane channel exhibiting pH-dependent Ca 2+ ion permeability with a selective response to Cu 2+ ions. The coordination structure at bpy sites depends on the pH and metal ions can control the association state of bpy-AmB in the membran...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-03, Vol.57 (23), p.2895-2898
Main Authors: Koshiyama, Tomomi, Inoue, Yuki, Asada, Sana, Kawahara, Koki, Ide, Shogo, Yasuhara, Kazuma, Ohba, Masaaki
Format: Article
Language:English
Subjects:
Calcium ions
Membranes
Permeability
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Summary:Amphotericin B incorporating 2,2′-bipyridine (bpy-AmB) forms a membrane channel exhibiting pH-dependent Ca 2+ ion permeability with a selective response to Cu 2+ ions. The coordination structure at bpy sites depends on the pH and metal ions can control the association state of bpy-AmB in the membrane. Amphotericin B incorporated with a metal-binding site within a membrane exhibited pH-dependent ion permeability with a response to Cu 2+ ions selectively.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc08368b