Metal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8ob00981c

The elemental sulfur-promoted oxidative cyclization reaction for the efficient synthesis of substituted imidazo[1,2- a ]pyridines has been developed. Easily available 2-aminopyridines and aldehydes were directly assembled in a highly atom-economical fashion through oxidative annulation under metal-...

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Main Authors: Tan, Jing, Ni, Penghui, Huang, Huawen, Deng, Guo-Jun
Format: Article
Language:English
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Summary:The elemental sulfur-promoted oxidative cyclization reaction for the efficient synthesis of substituted imidazo[1,2- a ]pyridines has been developed. Easily available 2-aminopyridines and aldehydes were directly assembled in a highly atom-economical fashion through oxidative annulation under metal- and base-free conditions. Besides arylacetaldehydes, aliphatic aldehydes were also compatible with this system to deliver the alkyl-substituted imidazo[1,2- a ]pyridines in excellent yields with the capability of gram-scale synthesis. An elemental sulfur-based metal- and base-free system enables oxidative imidazo[1,2- a ]pyridine annulations.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob00981c