Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitorElectronic supplementary information (ESI) available: Supplementary figures, experimental section, and compound characterization. See DOI: 10.1039/c8cc01154k

Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992 , containing a novel scaffold based on the tetrahydro-3 H -pyrazolo[4,3- a ]phenanthridine core, inhibits CDK2/3 but not other CDKs and also potently inhibits several cancer cell lines. Cyclin-dependent kinases hav...

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Main Authors: Opoku-Temeng, Clement, Dayal, Neetu, Hernandez, Delmis E, Naganna, N, Sintim, Herman O
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Summary:Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992 , containing a novel scaffold based on the tetrahydro-3 H -pyrazolo[4,3- a ]phenanthridine core, inhibits CDK2/3 but not other CDKs and also potently inhibits several cancer cell lines. Cyclin-dependent kinases have emerged as important targets for cancer therapy.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc01154k