Chemical decontamination of iPS cell-derived neural cell mixturesElectronic supplementary information (ESI) available. See DOI: 10.1039/c7cc08686e

This report describes the design and evaluation of phosphorylated 7-ethyl-10-hydroxycamptothecin (SN38-P), which selectively eliminates tumor-forming proliferative stem cells, including human induced pluripotent stem cells (hiPSCs) and neural stem cells, from iPSC-derived neural cell mixtures. Resul...

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Main Authors: Mao, Di, Chung, Xie Khim Watson, Andoh-Noda, Tomoko, Qin, Ying, Sato, Shin-ichi, Takemoto, Yasushi, Akamatsu, Wado, Okano, Hideyuki, Uesugi, Motonari
Format: Article
Language:English
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Summary:This report describes the design and evaluation of phosphorylated 7-ethyl-10-hydroxycamptothecin (SN38-P), which selectively eliminates tumor-forming proliferative stem cells, including human induced pluripotent stem cells (hiPSCs) and neural stem cells, from iPSC-derived neural cell mixtures. Results of the present study demonstrate that simple phosphorylation of an anticancer drug can provide a safe, cost-effective, and chemically-defined tool for decontaminating hiPSC-derived neuron. Simple phosphorylation of an anticancer drug provides a safe, cost-effective, and chemically-defined tool for decontaminating hiPSC-derived neurons.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc08686e