The Co3O4 nanoparticle-enhanced luminol-O2 chemiluminescence reaction used for the determination of nortriptyline hydrochloride and lamotrigine in pharmaceutical and environmental samples

Spherical, cubic and plate-like Co 3 O 4 nanoparticles (NPs) were synthesised and, then, were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). It was found that Co 3 O 4 NPs posses...

Full description

Saved in:
Bibliographic Details
Published in:Analytical methods 2018-01, Vol.1 (4), p.429-438
Main Authors: Iranifam, Mortaza, Hendekhale, Nasim Rahmati, Al Lawati, Haider A. J
Format: Article
Language:English
Subjects:
Chemiluminescence
Cobalt oxides
Electron microscopy
Fourier transforms
Infrared spectroscopy
Lamotrigine
Microscopy
Nanoparticles
Nanospheres
Pharmaceuticals
Scanning electron microscopy
Transmission electron microscopy
X-ray diffraction
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Spherical, cubic and plate-like Co 3 O 4 nanoparticles (NPs) were synthesised and, then, were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). It was found that Co 3 O 4 NPs possess oxidase-like activity and could enhance the intensity of the CL reaction. The enhancing effect of Co 3 O 4 NPs on the CL reaction was dependent on the shape of the Co 3 O 4 NPs. It increased in the order of Co 3 O 4 nanoplates (NPLs) < Co 3 O 4 nanocubes (NCs) < Co 3 O 4 nanospheres (NSs). Moreover, it was found that nortriptyline (NT) and lamotrigine (LTG) could quench the Co 3 O 4 NSs-luminol-O 2 CL reaction. Based on these findings, simple and sensitive CL methods for the determination of NT and LTG were proposed. The linear dynamic ranges of the CL methods were 1.0 × 10 −6 -1.0 × 10 −4 mol L −1 , with a limit of detection (LOD) = 5.2 × 10 −7 mol L −1 for NT and 7.0 × 10 −7 -1.0 × 10 −4 mol L −1 , with a LOD = 2.8 × 10 −7 mol L −1 for LTG. The relative standard deviation (RSD) of the CL methods was 3.6 and 2.7 ( n = 9) for the determination of 1.0 × 10 −6 mol L −1 NT and LTG, respectively. The CL method was used for the measurement of NT and LTG in pharmaceutical preparations and spiked tap waters. Co 3 O 4 NPs possess oxidase-like activity and could enhance the intensity of the CL reaction. The enhancing effect of Co 3 O 4 NPs on the CL reaction was dependent on the shape of the Co 3 O 4 NPs.
ISSN:1759-9660
1759-9679
DOI:10.1039/c7ay02227a