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Identification of different tumor states in nasopharyngeal cancer using surface-enhanced Raman spectroscopy combined with Lasso-PLS-DA algorithm
Identification of different states in cancer is of vital importance for cancer treatment and management. A powerful diagnostic algorithm based on Lasso-partial least squares-discriminant analysis (Lasso-PLS-DA) was developed here for improving blood surface-enhanced Raman spectroscopy (SERS) analysi...
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Published in: | RSC advances 2016-01, Vol.6 (1), p.776-7764 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Identification of different states in cancer is of vital importance for cancer treatment and management. A powerful diagnostic algorithm based on Lasso-partial least squares-discriminant analysis (Lasso-PLS-DA) was developed here for improving blood surface-enhanced Raman spectroscopy (SERS) analysis, with the aim to classify different states in nasopharyngeal cancer (NPC). A total of 160 blood plasma samples were collected for this study, obtained from 60 normal volunteers, 25 T1 stage cancer and 75 T2-T4 stages cancer patients. Results show that a diagnostic sensitivity of 68% and a specificity of 84.0% can be achieved for separating T2-T4 stage from T1 stage cancer, which had a 20% improvement in diagnostic specificity compared with the previous work. This exploratory study demonstrates that the Lasso-PLS-DA can be integrated with blood SERS analysis as a promising clinical complement for different T stages detection in NPC.
Identification of different states in cancer is of vital importance for cancer treatment and management. |
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ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/c5ra24438b |