A Pd(ii)-catalyzed C-H activation approach to densely functionalized N-heteroaromatics related to neocryptolepine and their evaluation as potential inducers of apoptosisElectronic supplementary information (ESI) available: Experimental procedures, spectral data for all new compounds, copies of spectra and results of zebrafish embryo study. See DOI: 10.1039/c5ra06764b

11-Carboxymethyl substituted 6 H -indolo[2,3- b ]quinolines, which are potential inducers of apoptosis, were obtained by one-pot Pd( ii )-catalyzed intramolecular oxidative C3-H alkenylation of the indole ring of ( E )-alkyl-3-(2-(1 H -indol-2-ylamino)phenyl)acrylate derivatives followed by desulfon...

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Main Authors: Sunke, Rajnikanth, Kumar, Vimal, Ashfaq, Mohd Ashraf, Yellanki, Swapna, Medisetti, Raghavender, Kulkarni, Pushkar, Shivaji Ramarao, E. V. Venkat, Ehtesham, Nasreen Z, Pal, Manojit
Format: Article
Language:English
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Summary:11-Carboxymethyl substituted 6 H -indolo[2,3- b ]quinolines, which are potential inducers of apoptosis, were obtained by one-pot Pd( ii )-catalyzed intramolecular oxidative C3-H alkenylation of the indole ring of ( E )-alkyl-3-(2-(1 H -indol-2-ylamino)phenyl)acrylate derivatives followed by desulfonylation. Bioactive indoloquinolines are synthesized via Pd( ii )-catalyzed intramolecular oxidative C-H alkenylation as the key step.
ISSN:2046-2069
DOI:10.1039/c5ra06764b