A nickel-mediated oxidative α-C(sp3)-H functionalization of amides with allylic alcohols terminated by radical 1,2-aryl migrationElectronic supplementary information (ESI) available. See DOI: 10.1039/c4cc08797f

A Ni-mediated oxidative C(sp 3 )-H functionalization of N , N -substituted amides with α,α-diaryl allylic alcohols through a radical 1,2-aryl migration process has been developed. This process features a broad substrate scope and excellent functional group tolerance. Notably, γ-amino ketones contain...

Full description

Saved in:
Bibliographic Details
Main Authors: Song, Ren-Jie, Tu, Yong-Qiang, Zhu, Dao-Yong, Zhang, Fu-Min, Wang, Shao-Hua
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A Ni-mediated oxidative C(sp 3 )-H functionalization of N , N -substituted amides with α,α-diaryl allylic alcohols through a radical 1,2-aryl migration process has been developed. This process features a broad substrate scope and excellent functional group tolerance. Notably, γ-amino ketones containing an all-carbon quaternary center were synthesized under these conditions in moderate to good yields. A Ni-mediated oxidative C(sp 3 )-H functionalization of N , N -substituted amides with α,α-diaryl allylic alcohols through a radical 1,2-aryl migration process has been developed. This process features a broad substrate scope and excellent functional group tolerance.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc08797f