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Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bondsElectronic supplementary information (ESI) available: Experimental procedures and full spectroscopic data are available. See DOI: 10.1039/c4cc02107j
Tuning the properties of maleimide reagents holds significant promise in expanding the toolbox of available methods for bioconjugation. Herein we describe aryloxymaleimides which represent 'next generation maleimides' of attenuated reactivity, and demonstrate their ability to enable new me...
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Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | Tuning the properties of maleimide reagents holds significant promise in expanding the toolbox of available methods for bioconjugation. Herein we describe aryloxymaleimides which represent 'next generation maleimides' of attenuated reactivity, and demonstrate their ability to enable new methods for protein modification at disulfide bonds.
Aryloxymaleimides represent 'next generation maleimides' of attenuated reactivity. We demonstrate their use in establishing novel bioconjugation procedures at disulfide bonds. |
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ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/c4cc02107j |