The first comparative study of the ability of different hydrophilic groups to water-solubilise fluorescent BODIPY dyesElectronic supplementary information (ESI) available: Characterisation/spectral data for compounds 1-12. See DOI: 10.1039/c3nj41093e

A green-emitting BODIPY dye carrying a carboxylic acid at the meso -phenyl ring was derivatised with a set of eight different hydrophilic groups neutral, negatively- or positively-charged at physiological pH. The determination of both partition coefficient (log P ) and fluorescence quantum yield ( Φ...

Full description

Saved in:
Bibliographic Details
Main Authors: Romieu, Anthony, Massif, Cédrik, Rihn, Sandra, Ulrich, Gilles, Ziessel, Raymond, Renard, Pierre-Yves
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A green-emitting BODIPY dye carrying a carboxylic acid at the meso -phenyl ring was derivatised with a set of eight different hydrophilic groups neutral, negatively- or positively-charged at physiological pH. The determination of both partition coefficient (log P ) and fluorescence quantum yield ( Φ F ) for each polar BODIPY dye allows building the first water-solubility scale for such fluorescent organic materials. This valuable tool can be used to select the most suitable molecular candidate for converting a hydrophobic BODIPY scaffold into a water-soluble and brightly fluorescent dye, and for tuning its net electric charge/polarity according to the biolabelling application targeted for this specific fluorescent marker. The first water-solubility scale of a library of green-emitting BODIPY dyes intended for biomolecular labelling applications.
ISSN:1144-0546
1369-9261
DOI:10.1039/c3nj41093e