Complete shift of ferritin oligomerization toward nanocage assembly via engineered protein-protein interactionsElectronic supplementary information (ESI) available. See DOI: 10.1039/c3cc40886h

Computational redesign of a dimorphic protein nano-cage at the C 3-symmetrical interfaces forces it to assemble into the monomorphic cage. These monodisperse assemblies are at least 20 °C more stable than the parent. This approach adds to the toolkit of bottom-up molecular design with applications i...

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Bibliographic Details
Main Authors: Ardejani, Maziar S, Chok, Xiao Ling, Foo, Ce Jin, Orner, Brendan P
Format: Article
Language:English
Online Access:Get full text
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Summary:Computational redesign of a dimorphic protein nano-cage at the C 3-symmetrical interfaces forces it to assemble into the monomorphic cage. These monodisperse assemblies are at least 20 °C more stable than the parent. This approach adds to the toolkit of bottom-up molecular design with applications in protein engineering and hybrid nano-materials. A straight-forward computational method is used to redesign protein-protein interfaces of a dimorphic nanocage forcing it to assemble with monomorphism.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc40886h