RNA binding and inhibition of primer extension by a Ru(iii)/Pt(ii) metal complexElectronic supplementary information (ESI) available: Full experimental details, quantified band intensity values, mobility shift assays at varying temperatures, and primer extension controls. See DOI: 10.1039/c3cc40699g

AH197, a trinuclear Ru( iii )/Pt( ii ) metal complex, is strikingly more effective than the hallmark anticancer drug cisplatin and the Ru( iii ) clinical candidate NAMI-A in its binding to RNA and inhibition of primer DNA synthesis. Heteromultinuclear complexes could potentially serve as far better...

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Main Authors: Jain, Swapan S, Anderson, Craig M, DiRienzo, Francesca, Taylor, Isabelle R, Jain, Kyan, Guha, Sumedha, Hoque, Nushrat
Format: Article
Language:English
Online Access:Get full text
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Summary:AH197, a trinuclear Ru( iii )/Pt( ii ) metal complex, is strikingly more effective than the hallmark anticancer drug cisplatin and the Ru( iii ) clinical candidate NAMI-A in its binding to RNA and inhibition of primer DNA synthesis. Heteromultinuclear complexes could potentially serve as far better chemotherapeutics than mononuclear complexes. AH197, a trinuclear Ru( iii )/Pt( ii ) metal complex, is strikingly more effective than the hallmark anticancer drug cisplatin and the Ru( iii ) clinical candidate NAMI-A in its binding to RNA and inhibition of primer DNA synthesis.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc40699g