Orthogonal synthesis of a heterodimeric ligand for the development of the GdIII-GaIII ditopic complex as a potential pH-sensitive MRI/PET probeElectronic supplementary information (ESI) available: HPLC methods and 1H and 13C NMR spectra. See DOI: 10.1039/c2ob27200h

A heterodimeric polyaminocarboxylate ligand based on a DO3A-sulfonamide linked to AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetracarboxylic acid) was synthesised via an orthogonal pathway in order to differentiate the two chelating cages and allow the formation of a Gd III -Ga III heteroditopic c...

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Bibliographic Details
Main Authors: Vologdin, Nikolay, Rolla, Gabriele A, Botta, Mauro, Tei, Lorenzo
Format: Article
Language:English
Online Access:Get full text
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Summary:A heterodimeric polyaminocarboxylate ligand based on a DO3A-sulfonamide linked to AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetracarboxylic acid) was synthesised via an orthogonal pathway in order to differentiate the two chelating cages and allow the formation of a Gd III -Ga III heteroditopic complex. The goal is to create a smart MRI/PET probe with pH dependent relaxivity and with the bimodal imaging approach that enables direct quantification of the stimulus, in this case pH. A 1 H NMR relaxometric study of the Gd-Ga heteroditopic complex addressed the pH modulation of the relaxivity and thus its possible use as an MRI pH sensitive probe. A heterodimeric DO3A-sulfonamide-AAZTA ligand and its Gd III -Ga III heteroditopic complex were synthesised via an orthogonal route aiming to build a platform for the preparation of an efficient smart MRI/PET probe sensitive to pH.
ISSN:1477-0520
1477-0539
DOI:10.1039/c2ob27200h