Chiral separation by enantioselective liquid-liquid extraction

The literature on enantioselective liquid-liquid extraction (ELLE) spans more than half a century of research. Nonetheless, a comprehensive overview has not appeared during the past few decades. Enantioselective liquid-liquid extraction is a technology of interest for a wide range of chemists and ch...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2011-01, Vol.9 (1), p.36-51
Main Authors: Schuur, Boelo, Verkuijl, Bastiaan J. V, Minnaard, Adriaan J, de Vries, Johannes G, Heeres, Hero J, Feringa, Ben L
Format: Article
Language:English
Subjects:
Models, Molecular
Molecular Conformation
Phase Transition
Stereoisomerism
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Summary:The literature on enantioselective liquid-liquid extraction (ELLE) spans more than half a century of research. Nonetheless, a comprehensive overview has not appeared during the past few decades. Enantioselective liquid-liquid extraction is a technology of interest for a wide range of chemists and chemical engineers in the fields of fine chemicals, pharmaceuticals, agrochemicals, fragrances and foods. In this review the principles and advances of resolution through enantioselective liquid-liquid extraction are discussed, starting with an introduction on the principles of enantioselective liquid-liquid extraction including host-guest chemistry, extraction and phase transfer mechanisms, and multistage liquid-liquid extraction processing. Then the literature on enantioselective liquid-liquid extraction systems is reviewed, structured on extractant classes. The following extractant classes are considered: crown ether based extractants, metal complexes and metalloids, extractants based on tartrates, and a final section with all other types of chiral extractants. In this review the principles of enantioselective liquid-liquid extraction are discussed, and extractant systems are reviewed, structured on extractant classes. The following classes are considered: crown ether based extractants, metal complexes and metalloids, extractants based on tartrates, and a final section with all other types of chiral extractants.
ISSN:1477-0520
1477-0539
DOI:10.1039/c0ob00610f