8p12 Stem Cell Myeloproliferative Disorder: the FOP-Fibroblast Growth Factor Receptor 1 Fusion Protein of the t(6;8) Translocation Induces Cell Survival Mediated by Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt/mTOR Pathways

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Published in:	Molecular and Cellular Biology 2001-12, Vol.21 (23), p.8129-8142
Main Authors:	Guasch, Géraldine, Ollendorff, Vincent, Borg, Jean-Paul, Birnbaum, Daniel, Pébusque, Marie-Josèphe
Format:	Article
Language:	eng
Subjects:	Animals Caspase 9 Caspase Inhibitors Cell Growth and Development Cell Line Cell Survival - drug effects chromosome 6 chromosome 8 Chromosomes, Human, Pair 6 - genetics Chromosomes, Human, Pair 8 - genetics DNA-Binding Proteins - metabolism Enzyme Inhibitors - pharmacology FOP gene Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Humans Isoenzymes - metabolism Leucine - genetics Life Sciences Mice mitogen-activated protein kinase Mitogen-Activated Protein Kinases - metabolism Mutagenesis, Site-Directed myeloproliferative disorders Myeloproliferative Disorders - genetics Myeloproliferative Disorders - metabolism Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Oncogene Proteins, Fusion - pharmacology Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide-3 Kinase Inhibitors Phospholipase C gamma Phosphorylation - drug effects Protein Kinases - metabolism Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-bcl-2 - metabolism Receptor Protein-Tyrosine Kinases - genetics Receptor, Fibroblast Growth Factor, Type 1 Receptors, Fibroblast Growth Factor - genetics Receptors, Fibroblast Growth Factor - metabolism Signal Transduction - physiology STAT1 Transcription Factor STAT3 Transcription Factor TOR Serine-Threonine Kinases Trans-Activators - metabolism Transfection Translocation, Genetic - genetics Type C Phospholipases - metabolism
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