Local connectivity and synaptic dynamics in mouse and human neocortex

We present a unique, extensive, and open synaptic physiology analysis platform and dataset. Through its application, we reveal principles that relate cell type to synaptic properties and intralaminar circuit organization in the mouse and human cortex. The dynamics of excitatory synapses align with t...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2022-03, Vol.375 (6585), p.eabj5861-eabj5861
Main Authors: Campagnola, Luke, Seeman, Stephanie C, Chartrand, Thomas, Kim, Lisa, Hoggarth, Alex, Gamlin, Clare, Ito, Shinya, Trinh, Jessica, Davoudian, Pasha, Radaelli, Cristina, Kim, Mean-Hwan, Hage, Travis, Braun, Thomas, Alfiler, Lauren, Andrade, Julia, Bohn, Phillip, Dalley, Rachel, Henry, Alex, Kebede, Sara, Alice, Mukora, Sandman, David, Williams, Grace, Larsen, Rachael, Teeter, Corinne, Daigle, Tanya L, Berry, Kyla, Dotson, Nadia, Enstrom, Rachel, Gorham, Melissa, Hupp, Madie, Dingman Lee, Samuel, Ngo, Kiet, Nicovich, Philip R, Potekhina, Lydia, Ransford, Shea, Gary, Amanda, Goldy, Jeff, McMillen, Delissa, Pham, Trangthanh, Tieu, Michael, Siverts, La'Akea, Walker, Miranda, Farrell, Colin, Schroedter, Martin, Slaughterbeck, Cliff, Cobb, Charles, Ellenbogen, Richard, Gwinn, Ryder P, Keene, C Dirk, Ko, Andrew L, Ojemann, Jeffrey G, Silbergeld, Daniel L, Carey, Daniel, Casper, Tamara, Crichton, Kirsten, Clark, Michael, Dee, Nick, Ellingwood, Lauren, Gloe, Jessica, Kroll, Matthew, Sulc, Josef, Tung, Herman, Wadhwani, Katherine, Brouner, Krissy, Egdorf, Tom, Maxwell, Michelle, McGraw, Medea, Pom, Christina Alice, Ruiz, Augustin, Bomben, Jasmine, Feng, David, Hejazinia, Nika, Shi, Shu, Szafer, Aaron, Wakeman, Wayne, Phillips, John, Bernard, Amy, Esposito, Luke, D'Orazi, Florence D, Sunkin, Susan, Smith, Kimberly, Tasic, Bosiljka, Arkhipov, Anton, Sorensen, Staci, Lein, Ed, Koch, Christof, Murphy, Gabe, Zeng, Hongkui, Jarsky, Tim
Format: Article
Language:English
Subjects:
Adult
Animal tissues
Animals
Brain
Cerebral cortex
Circuits
Cognition
Cognitive ability
Computational neuroscience
Computer architecture
Cytology
Data analysis
Datasets
Datasets as Topic
Dynamics
Electrophysiology
Excitatory Postsynaptic Potentials
Female
Historical account
Humans
Inhibitory Postsynaptic Potentials
Latency
Learning algorithms
Machine learning
Male
Mice
Mice, Transgenic
Microelectrodes
Models, Neurological
Neocortex
Neocortex - cytology
Neocortex - physiology
Nervous system
Network latency
Neural networks
Neural Pathways
Neurons
Neurons - physiology
Neurosciences
Quantal release
Species
Stochasticity
Substrates
Synapses
Synapses - physiology
Synaptic plasticity
Synaptic Transmission
Temporal Lobe - cytology
Temporal Lobe - physiology
Tissues
Visual Cortex - cytology
Visual Cortex - physiology
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Description
Summary:We present a unique, extensive, and open synaptic physiology analysis platform and dataset. Through its application, we reveal principles that relate cell type to synaptic properties and intralaminar circuit organization in the mouse and human cortex. The dynamics of excitatory synapses align with the postsynaptic cell subclass, whereas inhibitory synapse dynamics partly align with presynaptic cell subclass but with considerable overlap. Synaptic properties are heterogeneous in most subclass-to-subclass connections. The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis accounts for substantial heterogeneity within the subclass. In the human cortex, excitatory-to-excitatory synaptic dynamics are distinct from those in the mouse cortex and vary with depth across layers 2 and 3.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.abj5861