A Critical Appraisal of the Diagnostic and Prognostic Utility of the Anti-Inflammatory Marker IL-37 in a Clinical Setting: A Case Study of Patients with Diabetes Type 2

The role of the cytokine interleukin-37 (IL-37) has been recognized in reversing inflammation-mediated metabolic costs. The aim was to evaluate the clinical utility of this cytokine as a diagnostic and prognostic marker in patients with type 2 diabetes (T2D). We included 170 older (median: 66 years)...

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Bibliographic Details
Published in:International journal of environmental research and public health 2023-02, Vol.20 (4), p.3695
Main Authors: Bosnić, Zvonimir, Babič, František, Anderková, Viera, Štefanić, Mario, Wittlinger, Thomas, Majnarić, Ljiljana Trtica
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - therapeutic use
Anti-inflammatory drugs
Biomarkers
C-reactive protein
Cardiovascular disease
Case studies
Complications
Cytokines
Cytokines - metabolism
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - drug therapy
Diabetic retinopathy
Diabetics
Diagnostic systems
Female
Frailty
Health care
Humans
Hypertension
Inflammation
Inflammation - metabolism
Interleukins
Laboratories
Malnutrition
Medical research
Medicine, Experimental
Metabolic disorders
Metabolic syndrome
Metabolism
Nutritional status
Obesity
Pathophysiology
Patients
Primary care
Prognosis
Regression analysis
Statistical analysis
Subgroups
Type 2 diabetes
Vein & artery diseases
Weight control
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Summary:The role of the cytokine interleukin-37 (IL-37) has been recognized in reversing inflammation-mediated metabolic costs. The aim was to evaluate the clinical utility of this cytokine as a diagnostic and prognostic marker in patients with type 2 diabetes (T2D). We included 170 older (median: 66 years) individuals with T2D (females: 95) and classified as primary care attenders to assess the association of factors that describe patients with plasma IL-37 levels (expressed as quartiles) using multinomial regression models. We determined the diagnostic ability of IL-37 cut-offs to identify diabetes-related complications or patient subgroups by using Receiver Operating Characteristic analysis (c-statistics). Frailty status was shown to have a suppressive effect on IL-37 circulating levels and a major modifying effect on associations of metabolic and inflammatory factors with IL-37, including the effects of treatments. Situations in which IL-37 reached a clinically significant discriminating ability included the model of IL-37 and C-Reactive Protein in differentiating among diabetic patients with low-normal/high BMI ((
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph20043695