Extracellular Vesicle-Encapsulated microRNAs as Novel Biomarkers of Lung Health

Early detection of respiratory diseases is critical to facilitate delivery of disease-modifying interventions. Extracellular vesicle-enriched microRNAs (EV-miRNAs) may represent reliable markers of early lung injury. Evaluate associations of plasma EV-miRNAs with lung function. The prospective NAS (...

Full description

Saved in:
Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2023-01, Vol.207 (1), p.50-59
Main Authors: Eckhardt, Christina M, Gambazza, Simone, Bloomquist, Tessa R, De Hoff, Peter, Vuppala, Aishwarya, Vokonas, Pantel S, Litonjua, Augusto A, Sparrow, David, Parvez, Faruque, Laurent, Louise C, Schwartz, Joel, Baccarelli, Andrea A, Wu, Haotian
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers - metabolism
Extracellular Vesicles
Health risk assessment
Humans
Longitudinal Studies
Lung - metabolism
Lung diseases
Lung Injury - diagnosis
Medical treatment
MicroRNAs
MicroRNAs - metabolism
Original
Prospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Early detection of respiratory diseases is critical to facilitate delivery of disease-modifying interventions. Extracellular vesicle-enriched microRNAs (EV-miRNAs) may represent reliable markers of early lung injury. Evaluate associations of plasma EV-miRNAs with lung function. The prospective NAS (Normative Aging Study) collected plasma EV-miRNA measurements from 1996-2015 and spirometry every 3-5 years through 2019. Associations of EV-miRNAs with baseline lung function were modeled using linear regression. To complement the individual miRNA approach, unsupervised machine learning was used to identify clusters of participants with distinct EV-miRNA profiles. Associations of EV-miRNA profiles with multivariate latent longitudinal lung function trajectories were modeled using log binomial regression. Biological functions of significant EV-miRNAs were explored using pathway analyses. Results were replicated in an independent sample of NAS participants and in the HEALS (Health Effects of Arsenic Longitudinal Study). In the main cohort of 656 participants, 51 plasma EV-miRNAs were associated with baseline lung function (false discovery rate-adjusted value 
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.202109-2208OC