[18F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study

  Purpose Meta -[ 18 F]fluorobenzylguanidine ([ 18 F]mFBG) is a positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging of tumours expressing the norepinephrine transporter. This pilot study investigates the feasibility of [ 18 F]mFBG PET-CT for imaging in neu...

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Published in:European journal of nuclear medicine and molecular imaging 2023-03, Vol.50 (4), p.1146-1157
Main Authors: Samim, Atia, Blom, Thomas, Poot, Alex J., Windhorst, Albert D., Fiocco, Marta, Tolboom, Nelleke, Braat, Arthur J. A. T., Viol, Sebastiaan L. Meyer, van Rooij, Rob, van Noesel, Max M., Lam, Marnix G. E. H., Tytgat, Godelieve A. M., de Keizer, Bart
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine
Cardiology
Child, Preschool
Computed tomography
Feasibility studies
Fluorine isotopes
Humans
Image resolution
Imaging
Injection
Lesions
Medical imaging
Medicine
Medicine & Public Health
Neuroblastoma
Neuroblastoma - diagnostic imaging
Neuroblastoma - pathology
Norepinephrine
Norepinephrine transporter
Nuclear Medicine
Oncology
Original
Original Article
Orthopedics
Pediatric
Photon emission
Pilot Projects
Positron emission
Positron emission tomography
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography - methods
Prospective Studies
Radioactive tracers
Radiology
Scanning
Scintigraphy
Single photon emission computed tomography
Soft tissues
Tomography
Tumors
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Summary:  Purpose Meta -[ 18 F]fluorobenzylguanidine ([ 18 F]mFBG) is a positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging of tumours expressing the norepinephrine transporter. This pilot study investigates the feasibility of [ 18 F]mFBG PET-CT for imaging in neuroblastoma. Methods In a prospective, single-centre study, we recruited children with neuroblastoma, referred for meta -[ 123 I]iodobenzylguanidine ([ 123 I]mIBG) scanning, consisting of total body planar scintigraphy in combination with single-photon emission computed tomography-CT (SPECT-CT). Within two weeks of [ 123 I]mIBG scanning, total body PET-CTs were performed at 1 h and 2 h after injection of [ 18 F]mFBG (2 MBq/kg). Detected tumour localisations on scan pairs were compared. Soft tissue disease was quantified by number of lesions and skeletal disease by SIOPEN score. Results Twenty paired [ 123 I]mIBG and [ 18 F]mFBG scans were performed in 14 patients (median age 4.9 years, n  = 13 stage 4 disease and n  = 1 stage 4S). [ 18 F]mFBG injection was well tolerated and no related adverse events occurred in any of the patients. Mean scan time for [ 18 F]mFBG PET-CT (9.0 min, SD 1.9) was significantly shorter than for [ 123 I]mIBG scanning (84.5 min, SD 10.5), p  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-022-06063-6