Coronary Artery Calcium Dispersion and Cause-Specific Mortality

Coronary artery calcium (CAC) measures subclinical atherosclerosis and improves risk stratification. CAC characteristics—including vessel(s) involved, number of vessels, volume, and density—have been shown to differentially impact risk. We assessed how dispersion—either the number of calcified vesse...

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Bibliographic Details
Published in:The American journal of cardiology 2023-03, Vol.191, p.76-83
Main Authors: Dudum, Ramzi, Dardari, Zeina A., Feldman, David I., Berman, Daniel S., Budoff, Matthew J., Miedema, Michael D., Nasir, Khurram, Rozanski, Alan, Rumberger, John A., Shaw, Leslee, Dzaye, Omar, Caínzos-Achirica, Miguel, Patel, Jaideep, Blaha, Michael J.
Format: Article
Language:English
Subjects:
Arteriosclerosis
Atherosclerosis
Blood vessels
Calcification
Calcification (ectopic)
Calcium
Cardiovascular disease
Cardiovascular Diseases
Cause of Death
Consortia
Coronary Angiography
Coronary Artery Disease
Coronary vessels
Coronary Vessels - diagnostic imaging
Density
Diabetes
Diabetes mellitus
Dispersion
Family medical history
Female
Genotype & phenotype
Heart diseases
Humans
Hyperlipidemia
Hypertension
Male
Metabolic disorders
Mortality
Phenotypes
Retrospective Studies
Risk Assessment
Risk Factors
Sensitivity analysis
Tomography
Vascular Calcification - diagnostic imaging
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Summary:Coronary artery calcium (CAC) measures subclinical atherosclerosis and improves risk stratification. CAC characteristics—including vessel(s) involved, number of vessels, volume, and density—have been shown to differentially impact risk. We assessed how dispersion—either the number of calcified vessels or CAC phenotype (diffuse, normal, and concentrated)—impacted cause-specific mortality. The CAC Consortium is a retrospective cohort of 66,636 participants without coronary heart disease (CHD) who underwent CAC scoring. This study included patients with CAC >0 (n = 28,147). CAC area, CAC density, and CAC phenotypes (derived from the index of diffusion = 1 – [CAC in most concentrated vessel/total Agatston score]) were calculated. The associations between CAC characteristics and cause-specific mortality were assessed. The participant details included (n = 28,147): mean age 58.3 years, 25% female, 89.6% White, and 66% had 2+ calcified vessels. Diabetes, hypertension, and hyperlipidemia were predictors of multivessel involvement (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2022.12.014