Sleep, circadian rhythm characteristics, and melatonin levels in later life adults with and without coronary artery disease

The purpose of this study was to conduct a comprehensive assessment of sleep and circadian rhythms in individuals with and without coronary artery disease (CAD). This was a cross-sectional study. Participants were 32 individuals, mean age = 70.9, female 46.9%, 19 with CAD, and 13 without CAD. We ass...

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Bibliographic Details
Published in:Journal of clinical sleep medicine 2023-02, Vol.19 (2), p.283-292
Main Authors: Moon, Chooza, Benson, Christopher J, Albashayreh, Alaa, Perkhounkova, Yelena, Burgess, Helen J
Format: Article
Language:English
Subjects:
Adult
Aged
Circadian Rhythm
Coronary Artery Disease
Cross-Sectional Studies
Female
Humans
Melatonin
Scientific Investigations
Sleep
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Summary:The purpose of this study was to conduct a comprehensive assessment of sleep and circadian rhythms in individuals with and without coronary artery disease (CAD). This was a cross-sectional study. Participants were 32 individuals, mean age = 70.9, female 46.9%, 19 with CAD, and 13 without CAD. We assessed sleep quality and 24-hour rest-activity rhythms for 14 days using wrist actigraphy and self-report measures, and circadian rhythm using dim light melatonin onset. Melatonin levels prior to habitual bedtime were significantly lower in individuals with CAD than in those without CAD (median area under the curve = 12.88 vs 26.33 pg/ml × h, = .049). The median circadian timing measured by dim light melatonin onset was the same for the 2 groups with 20:26 [hours:minutes] for individuals with CAD and 19:53 for the control group ( = .64, = .14). Compared to the control group, the CAD group had significantly lower amplitude ( = .03, =-.48), and lower overall rhythmicity (pseudo- -statistic = .004, = -.65) in their 24-hour rest-activity rhythms. This is one of the first studies to comprehensively assess both sleep and circadian rhythm in individuals with CAD. Compared to non-CAD controls, individuals with CAD had lower levels of melatonin prior to habitual bedtime and a lower 24-hour rest-activity rhythm amplitude and overall rhythmicity. Future studies using larger sample sizes should further investigate the possibility of suppressed circadian rhythmicity in individuals with CAD. Moon C, Benson CJ, Albashayreh A, Perkhounkova Y, Burgess HJ. Sleep, circadian rhythm characteristics, and melatonin levels in later life adults with and without coronary artery disease. . 2023;19(2):283-292.
ISSN:1550-9389
1550-9397
DOI:10.5664/jcsm.10308