Epidemiology of heart failure in young adults: a French nationwide cohort study

Heart failure (HF) in young adults is uncommon, and changes in its incidence and prognosis in recent years are poorly described. The incidence and prognosis of HF in young adults (1850 years) were characterized using nationwide medico-administrative data from the French National Hospitalization Data...

Full description

Saved in:
Bibliographic Details
Published in:European heart journal 2023-02, Vol.44 (5), p.383-392
Main Authors: Lecoeur, Emmanuel, Domeng, Orianne, Fayol, Antoine, Jannot, Anne-Sophie, Hulot, Jean-Sbastien
Format: Article
Language:English
Subjects:
Adult
Clinical Research
Cohort Studies
Coronary Artery Disease - complications
Diabetes Mellitus - epidemiology
Heart Failure
Hospitalization
Humans
Incidence
Infant
Life Sciences
Male
Middle Aged
Myocardial Ischemia - complications
Risk Factors
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Heart failure (HF) in young adults is uncommon, and changes in its incidence and prognosis in recent years are poorly described. The incidence and prognosis of HF in young adults (1850 years) were characterized using nationwide medico-administrative data from the French National Hospitalization Database (period 20132018). A total of 1,486 877 patients hospitalized for incident HF were identified, including 70 075 (4.7) patients aged 1850 years (estimated incidence of 0.44 for this age group). During the study period, the overall incidence of HF tended to decrease in the overall population but significantly increased by 0.041 in young adults (P 0.001). This increase was notably observed among young men (from 0.51 to 0.59, P 0.001), particularly those aged 3650 years. In these young men, ischaemic heart disease (IHD) was the most frequently reported cause of HF, whereas non-ischaemic HF was mainly observed in patients 35 years old. In contrast to non-ischaemic HF, the incidence of IHD increased over the study period, which suggests that IHD-related HF is progressively affecting younger patients. Concordantly, young HF patients presented with high rates of traditional IHD risk factors, including obesity, smoking, hypertension, dyslipidaemia, or diabetes. Lastly, the rates of re-hospitalization (for HF or for any cause) within two years after the first HF event and in-hospital mortality were high in all groups, indicating a poor-prognosis population. Strategies for the prevention of HF risk factors should be strongly considered for patients under 50 years old.
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehac651