Maternal occupational exposure to chemicals and child cognitive function

Limited data exist regarding child neurodevelopment in relation to maternal occupational exposure to endocrine-disrupting chemicals (EDCs). We included 1058 mother-child pairs from the INfancia y Medio Ambiente (INMA) project (2003-2008). Using a job-exposure matrix, exposure probability scores for...

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Bibliographic Details
Published in:Pediatric research 2022-10, Vol.92 (4), p.1153-1160
Main Authors: Ish, Jennifer, Symanski, Elaine, Gimeno Ruiz de Porras, David, Casas, Maribel, Delclos, George L, Guxens, Mònica, Ibarluzea, Jesús M, Iñiguez, Carmen, Lertxundi, Aitana, Rebagliato, Marisa, Swartz, Michael D, Whitworth, Kristina W
Format: Article
Language:English
Subjects:
Children & youth
Cognition
Cognition & reasoning
Endocrine Disruptors - toxicity
Female
Humans
Maternal Exposure - adverse effects
Occupational Exposure - adverse effects
Pesticides
Polycyclic Aromatic Hydrocarbons
Pregnancy
Prospective Studies
Solvents
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Summary:Limited data exist regarding child neurodevelopment in relation to maternal occupational exposure to endocrine-disrupting chemicals (EDCs). We included 1058 mother-child pairs from the INfancia y Medio Ambiente (INMA) project (2003-2008). Using a job-exposure matrix, exposure probability scores for ten EDC groups were assigned to each mother based on her longest held job during pregnancy. At the child's 5-year visit, the McCarthy Scales of Children's Abilities was administered, yielding the general cognitive index and scales for specific cognitive domains. We analyzed region-specific associations between EDC exposures and each outcome separately using adjusted linear regression and combined region-specific effect estimates using random-effects meta-analyses. Approximately 24% of women were exposed to at least one EDC group, but exposure to most individual EDC groups was low (
ISSN:0031-3998
1530-0447
1530-0447
DOI:10.1038/s41390-022-02089-6