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Appendiceal goblet cell carcinoma has marginal advantages from perioperative chemotherapy: a population-based study with an entropy balancing analysis
Purpose The aim is to clarify the use of perioperative chemotherapy in resectable goblet cell carcinoma (GCC). Methods A retrospective study was carried out based on the Surveillance, Epidemiology, and End Results study. The population was divided: into patients who received only radical surgery (gr...
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Published in: | Langenbeck's archives of surgery 2023-01, Vol.408 (1), p.65-65, Article 65 |
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Main Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | Purpose
The aim is to clarify the use of perioperative chemotherapy in resectable goblet cell carcinoma (GCC).
Methods
A retrospective study was carried out based on the Surveillance, Epidemiology, and End Results study. The population was divided: into patients who received only radical surgery (group A) and those who received radical surgery plus chemotherapy (group B). An entropy balancing was carried out to correct the imbalance between the two groups. Two models were generated. Model 1 contained only high-risk patients: group B and a “virtual” group A with similar characteristics. Model 2 included only low-risk patients: group A and “virtual” group B with identical attributes. The efficacy of entropy balancing was evaluated with the
d
value. The overall survival was compared and reported with Hazard Ratio (HR) within a confidence interval of 95% (95 CI).
Results
The groups A and B were imbalanced for tumor size (
d
= 0.392), T (
d
= 1.128), N (
d
= 1.340), M (
d
= 1.456), mean number of positive lymph nodes (
d
= 0.907), and LNR (
d
= 0.889). Before the balancing, the risk of death was higher in group B than in A (4.3; 2.5 to 7.4). After reweighting, all large differences were eliminated (
d
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ISSN: | 1435-2451 1435-2443 1435-2451 |
DOI: | 10.1007/s00423-023-02791-x |