Cerebral O2 and CO2 transport in isovolumic haemodilution: Compensation of cerebral delivery of O2 and maintenance of cerebrovascular reactivity to CO2

This study investigated the influence of acute reductions in arterial O2 content (CaO2) via isovolumic haemodilution on global cerebral blood flow (gCBF) and cerebrovascular CO2 reactivity (CVR) in 11 healthy males (age; 28 ± 7 years: body mass index; 23 ± 2 kg/m2). Radial artery and internal jugula...

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Bibliographic Details
Published in:	Journal of cerebral blood flow and metabolism 2023-01, Vol.43 (1), p.99-114
Main Authors:	Carr, Jay MJR, Ainslie, Philip N, MacLeod, David B, Tremblay, Joshua C, Nowak-Flück, Daniela, Howe, Connor A, Stembridge, Mike, Patrician, Alexander, Coombs, Geoff B, Stacey, Benjamin S, Bailey, Damian M, Green, Daniel J, Hoiland, Ryan L
Format:	Article
Language:	eng
Subjects:	Original
Online Access:	Get full text
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Summary:	This study investigated the influence of acute reductions in arterial O2 content (CaO2) via isovolumic haemodilution on global cerebral blood flow (gCBF) and cerebrovascular CO2 reactivity (CVR) in 11 healthy males (age; 28 ± 7 years: body mass index; 23 ± 2 kg/m2). Radial artery and internal jugular vein catheters provided measurement of blood pressure and gases, quantification of cerebral metabolism, cerebral CO2 washout, and trans-cerebral nitrite exchange (ozone based chemiluminescence). Prior to and following haemodilution, the partial pressure of arterial CO2 (PaCO2) was elevated with dynamic end-tidal forcing while gCBF was measured with duplex ultrasound. CVR was determined as the slope of the gCBF response and PaCO2. Replacement of ∼20% of blood volume with an equal volume of 5% human serum albumin (Alburex® 5%) reduced haemoglobin (13.8 ± 0.8 vs. 11.3 ± 0.6 g/dL; P
ISSN:	0271-678X 1559-7016