Association between Human Papillomavirus and Oral Cancer in Iranian Clinical Samples: A Meta-Analysis Review

Oral squamous cell carcinoma (OSCC) is one of the most common malignancies and is a serious problem worldwide. The role of HPV in oral cavity squamous cell carcinoma has been studied in several researches. This present review and meta-analysis aimed to investigate the relation between human papillom...

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Bibliographic Details
Published in:Iranian journal of public health 2022-12, Vol.51 (12), p.2688-2696
Main Authors: Haghshenas, Mohammad Reza, Moosazadeh, Mahmood, Taghiloo, Saeid, Sattari, Sogol, Valadan, Reza, Mousavi, Tahoora
Format: Article
Language:English
Subjects:
Cancer
Health risks
Heterogeneity
Human papillomavirus
Infections
Malignancy
Meta-analysis
Oral cancer
Oral carcinoma
Oral cavity
Oral squamous cell carcinoma
Review
Statistical analysis
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Summary:Oral squamous cell carcinoma (OSCC) is one of the most common malignancies and is a serious problem worldwide. The role of HPV in oral cavity squamous cell carcinoma has been studied in several researches. This present review and meta-analysis aimed to investigate the relation between human papillomavirus (HPV) and oral cancer. Relevant studies were found using online international databases including Science direct, Web of science (ISI), PubMed, Scopus, Embase, and Google scholar, to determine relevant studies published between 2000 and Jan 2020. Suitable studies were selected and assessed by two independent researchers. The quality of all papers were determined by a checklist. Heterogeneity assay among the primary studies was evaluated by Cochran's Q test and I2 index. The statistical analyses were done using Stata SE, V.11 software. Trim and Fill method was applied to confirm the validity of the results. This meta-analysis consists of 8 primary studies on the incidence of HPV infection in Iranian patients with oral diseases. The odds ratio between HPV infection and risk of oral cancer was 4.00 (95%CI: 2.31, 6.93). This meta-analysis showed associations between prevalence of HPV infection and oral cancer among Iranian patients. The chance of developing oral cancer among HPV positive patients was higher than that in HPV negative patients.
ISSN:2251-6085
2251-6093
DOI:10.18502/ijph.v51i12.11459