S-Fimbria-encoding determinant sfaI is located on pathogenicity Island III536 of uropathogenic Escherichia coli strain 536

The sfa I determinant encoding the S-fimbrial adhesin of uropathogenic Escherichia coli strains was found to be located on a pathogenicity island of uropathogenic E. coli strain 536. This pathogenicity island, designated PAI III 536 , is located at 5.6 min of the E. coli chromosome and covers a regi...

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Bibliographic Details
Published in:Infection and immunity 2001-07, Vol.69 (7), p.4248-4256
Main Authors: DOBRINDT, Ulrich, BLUM-OEHLER, Gabriele, HARTSCH, Thomas, GOTTSCHALK, Gerhard, RON, Eliora Z, FÜNFSTÜCK, Reinhard, HACKER, Jörg
Format: Article
Language:English
Subjects:
Bacteriology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Genetics
Microbiology
Molecular Genomics
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
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Summary:The sfa I determinant encoding the S-fimbrial adhesin of uropathogenic Escherichia coli strains was found to be located on a pathogenicity island of uropathogenic E. coli strain 536. This pathogenicity island, designated PAI III 536 , is located at 5.6 min of the E. coli chromosome and covers a region of at least 37 kb between the tRNA locus thrW and yagU . As far as it has been determined, PAI III 536 also contains genes which code for components of a putative enterochelin siderophore system of E. coli and Salmonella spp. as well as for colicin V immunity. Several intact or nonfunctional mobility genes of bacteriophages and insertion sequence elements such as transposases and integrases are present on PAI III 536 . The presence of known PAI III 536 sequences has been investigated in several wild-type E. coli isolates. The results demonstrate that the determinants of the members of the S-family of fimbrial adhesins may be located on a common pathogenicity island which, in E. coli strain 536, replaces a 40-kb DNA region which represents an E. coli K-12-specific genomic island.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.69.7.4248-4256.2001