Implications of biomimetic nanocarriers in targeted drug delivery

Nanomaterials and nanostructures have shown fascinating performances in various biomedicine fields, from cosmetic to cancer diagnosis and therapy. Engineered nanomaterials can encapsulate both lipophilic and hydrophilic substances/drugs to eliminate their limitations in the free forms, such as low b...

Full description

Saved in:
Bibliographic Details
Published in:Emergent materials (Online) 2023-02, Vol.6 (1), p.1-13
Main Authors: Al-Hetty, Hussein Riyadh Abdul Kareem, Kadhim, Maitha Sameer, Al-Tamimi, Jabbar Hassoon Zamil, Ahmed, Nahid Mahmood, Jalil, Abduladheem Turki, Saleh, Marwan Mahmood, Kandeel, Mahmoud, Abbas, Ruaa H.
Format: Article
Language:English
Subjects:
Chemistry and Materials Science
Energy Materials
Materials Engineering
Materials Science
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nanomaterials and nanostructures have shown fascinating performances in various biomedicine fields, from cosmetic to cancer diagnosis and therapy. Engineered nanomaterials can encapsulate both lipophilic and hydrophilic substances/drugs to eliminate their limitations in the free forms, such as low bioavailability, multiple drug administration, off-target effects, and various side effects. Moreover, it is possible to deliver the loaded cargo to the desired site of action using engineered nanomaterials. One approach that has made nanocarriers more sophisticated is the “biomimetic” concept. In this scenario, biomolecules (e.g., natural proteins, peptides, phospholipids, cell membranes) are used as building blocks to construct nanocarriers and/or modify agents. For instance, it has been reported that specific cells tend to migrate to a particular site during specific circumstances (e.g., inflammation, tumor formation). Employing the cell membrane of these cells as a coating for nanocarriers confers practical targeting approaches. Accordingly, we introduce the biomimetic concept in the current study, review the recent studies, challenge the issues, and provide practical solutions.
ISSN:2522-5731
2522-574X
DOI:10.1007/s42247-023-00453-8