Emerging Options for the Prevention and Management of Clostridioides difficile Infection

Agents in development for the prevention or treatment of Clostridioides difficile infection can be split into three broad categories: antibiotics, microbiome restoration, and vaccines. Given the extensive list of agents currently in development, this narrative review will focus on agents that have p...

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Bibliographic Details
Published in:Drugs (New York, N.Y.) N.Y.), 2023-02, Vol.83 (2), p.105-116
Main Authors: Gonzales-Luna, Anne J., Carlson, Travis J., Garey, Kevin W.
Format: Article
Language:English
Subjects:
Acids
Anti-Bacterial Agents - therapeutic use
Antibiotics
Bile
Clinical medicine
Clinical practice guidelines
Clinical trials
Clostridioides difficile
Clostridium Infections - drug therapy
Clostridium Infections - prevention & control
Humans
Infections
Internal Medicine
Leading
Leading Article
Medicine
Medicine & Public Health
Microbiomes
Microbiota
Pharmacology/Toxicology
Pharmacotherapy
Prevention
Toxoids - therapeutic use
Vaccines
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Summary:Agents in development for the prevention or treatment of Clostridioides difficile infection can be split into three broad categories: antibiotics, microbiome restoration, and vaccines. Given the extensive list of agents currently in development, this narrative review will focus on agents that have progressed into late-stage clinical trials, defined as having a Phase III clinical trial registered on ClinicalTrials.gov. These agents include one antibiotic (ridinilazole), three live biotherapeutic products (LBPs) (CP101, RBX2660, and SER109), and two toxoid vaccines (PF06425090 and a second toxoid vaccine). As new prevention and treatment strategies enter the market, clinicians and administrators will need knowledge of these products to make rational decisions on how best to adopt them into clinical practice.
ISSN:0012-6667
1179-1950
DOI:10.1007/s40265-022-01832-x