Changes in corneal endothelial cell density after initial Ex-PRESS drainage device implantation and its relating factors over 3 years

To investigate changes in corneal endothelial cell density (CECD) after initial Ex-PRESS surgery in Japanese patients with open-angle glaucoma (OAG) followed-up for 36 months. Corneal specular microscopy was used to examine preoperative and postoperative (3, 6, 12, 24 and 36 months) CECD and CECD ch...

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Bibliographic Details
Published in:Eye (London) 2023-01, Vol.37 (1), p.69-74
Main Authors: Aoyama, Yurika, Sakata, Rei, Fujishiro, Takashi, Honjo, Megumi, Shirato, Shiroaki, Aihara, Makoto
Format: Article
Language:English
Subjects:
Cataracts
Cell density
Cornea
Endothelial Cells
Endothelium, Corneal
Follow-Up Studies
Glaucoma
Glaucoma Drainage Implants
Glaucoma, Open-Angle - surgery
Humans
Intraocular Pressure
Risk factors
Surgery
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Summary:To investigate changes in corneal endothelial cell density (CECD) after initial Ex-PRESS surgery in Japanese patients with open-angle glaucoma (OAG) followed-up for 36 months. Corneal specular microscopy was used to examine preoperative and postoperative (3, 6, 12, 24 and 36 months) CECD and CECD changes were analysed. Kaplan-Meier survival curve was used to examine CECD maintained at 95% level, and Cox proportional hazards model was used to detect the risk factors for CECD loss. Intraocular pressure (IOP) changes during the course were also examined. A total of 79 eyes of 79 patients (standalone surgery, 24 cases; combined cataract surgery, 55 cases) were investigated. Preoperative CECD (mean ± SD) was 2521 ± 305 cells/mm² and 2429 ± 366 (P = 0.003, adjusted for Bonferroni correction), 2462 ± 332 (P = 0.002), 2457 ± 317 (P 
ISSN:0950-222X
1476-5454
DOI:10.1038/s41433-021-01888-1