Characteristics & outcomes of cancer patients with COVID-19: A multicentre retrospective study from India

Background & objectives: High mortality has been observed in the cancer population affected with COVID-19 during this pandemic. We undertook this study to determine the characteristics and outcomes of cancer patients with COVID-19 and assessed the factors predicting outcome. Methods: Patients of...

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Published in:Indian journal of medical research (New Delhi, India : 1994) India : 1994), 2022-05, Vol.155 (5), p.546-553
Main Authors: Kumar, Akash, Baghmar, Saphalta, Mehta, Prashant, Tiwari, Priya, Kumar, Lalit, Bakhshi, Sameer, Agarwal, Amit, Gupta, Ishaan, Trikha, Anjan, Bhatnagar, Sushma, Gogia, Ajay, Malik, Prabhat, Sahoo, Ranjit, Rastogi, Sameer, Pramanik, Raja, Batra, Atul, Pushpam, Deepam, Sharma, Chitresh, Sharma, Vinod, Kataria, Babita, Goyal, Kapil, Samaga, Shreyas, Bothra, Sneha, Sharma, Atul
Format: Article
Language:English
Subjects:
Aged
Asymptomatic
Breast cancer
Cancer
Cancer patients
Chemotherapy
Coronaviruses
COVID-19
Demographic aspects
Hospital patients
Humans
India - epidemiology
Middle Aged
Mortality
Neoplasms - complications
Neoplasms - epidemiology
Neutropenia
Neutropenia - complications
Original
Retrospective Studies
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Statistics
Tumors
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Summary:Background & objectives: High mortality has been observed in the cancer population affected with COVID-19 during this pandemic. We undertook this study to determine the characteristics and outcomes of cancer patients with COVID-19 and assessed the factors predicting outcome. Methods: Patients of all age groups with a proven history of malignancy and a recent diagnosis of SARS-CoV-2 infection based on nasal/nasopharyngeal reverse transcriptase (RT)-PCR tests were included. Demographic, clinical and laboratory variables were compared between survivors and non-survivors groups, with respect to observed mortality. Results: Between May 11 and August 10, 2020, 134 patients were included from the three centres and observed mortality was 17.1 per cent. The median age was 53 yr (interquartile range 39-61 yr) and thirty four patients (25%) were asymptomatic. Solid tumours accounted for 69.1 per cent and breast cancer was the most common tumour type (20%). One hundred and five patients (70.5%) had received chemotherapy within the past four weeks and 25 patients (19.3%) had neutropenia at presentation. On multivariate analysis, age [odds ratio (OR) 7.99 (95% confidence interval [CI] 1.18-54.00); P=0.033], haemoglobin [OR 6.28 (95% CI 1.07-37.04); P=0.042] neutrophil-lymphocyte ratio [OR 12.02 (95% CI 2.08-69.51); P=0.005] and baseline serum albumin [OR 18.52 (95% CI 2.80-122.27); P=0.002], were associated with higher mortality. Recent chemotherapy, haematological tumours type and baseline neutropenia did not affect the outcome. Interpretation & conclusions: Higher mortality in moderate and severe infections was associated with baseline organ dysfunction and elderly age. Significant proportion of patients were asymptomatic and might remain undetected.
ISSN:0971-5916
0975-9174
DOI:10.4103/ijmr.ijmr_1703_21