Congenital cytomegalovirus infection with brainstem hemorrhage and polymicrogyria: Necropsic and histopathological findings

Congenital cytomegalovirus (CMV) infection can cause severe neurological sequelae or even fetal death. We present a 17‐year‐old pregnant woman with fetal CMV infection, leading to voluntary termination of pregnancy. Fetopsy demonstrated a brainstem hemorrhage and focal polymicrogyria. CMV inclusions...

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Bibliographic Details
Published in:Congenital anomalies 2022-11, Vol.62 (6), p.248-253
Main Authors: Arredondo Montero, Javier, Bronte Anaut, Mónica, Caballero Martínez, María Cristina, Fernández Seara, Maria Pilar, Martín‐Calvo, Nerea
Format: Article
Language:English
Subjects:
Adolescent
Brain Stem
Central nervous system
congenital
Cytomegalovirus
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - congenital
Cytomegalovirus Infections - diagnosis
Female
Fetuses
Hemorrhage
Hemorrhage - complications
Humans
Inclusions
infection
Infections
intracranial hemorrhage
Neurological complications
Polymicrogyria
Polymicrogyria - complications
Polymicrogyria - diagnosis
Pregnancy
Pregnancy Complications, Infectious
Short Communication
Thyroid
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Summary:Congenital cytomegalovirus (CMV) infection can cause severe neurological sequelae or even fetal death. We present a 17‐year‐old pregnant woman with fetal CMV infection, leading to voluntary termination of pregnancy. Fetopsy demonstrated a brainstem hemorrhage and focal polymicrogyria. CMV inclusions were observed in the lung, liver, thyroid, pancreas, kidneys, adrenal, placenta, and central nervous system. Intracranial hemorrhage is a rare finding in the context of congenital CMV infection, with isolated brainstem hemorrhage being an exceptional form of presentation. Polymicrogyria appears to be a more frequent finding, although its actual incidence is unknown. Future studies are needed to determine the causal association.
ISSN:0914-3505
1741-4520
DOI:10.1111/cga.12488