Focal Segmental Glomerulosclerosis Followed by Granuloma and Preceding T-Cell Lymphoma by 46 Months: A Continuation Process or Coincidence

Focal segmental glomerulosclerosis is a severe renal disease with a complex and unclear pathophysiology. Nephrotic syndrome is the clinical presentation of this renal disease. The recurrence of the disease after renal transplantation and the remission obtained after immune-adsorption treatment illus...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2022-11, Vol.14 (11), p.e31847
Main Authors: Tahri, Samah, Bachir, Houda, Hamaz, Siham, Belefqih, Ismail, Malki, Samia, Bennani, Amal, Alaoui, Habiba, Serraj, Khalid
Format: Article
Language:English
Subjects:
Autoimmune diseases
Biopsy
Blood tests
Bone marrow
Case reports
Chemotherapy
Disease
Edema
Epidemics
Epidemiology
Etiology
Hematology
Immune system
Infections
Infectious Disease
Inflammation
Internal Medicine
Lymphoma
Necrosis
Proteins
Pruritus
Steroids
Substance abuse treatment
Tuberculosis
Tumors
Urine
Viral infections
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Summary:Focal segmental glomerulosclerosis is a severe renal disease with a complex and unclear pathophysiology. Nephrotic syndrome is the clinical presentation of this renal disease. The recurrence of the disease after renal transplantation and the remission obtained after immune-adsorption treatment illustrate the implication of a circulating factor that requires characterization. Granulomatous inflammation is a tissue reaction caused by several conditions, including neoplastic diseases. In the literature, focal segmental glomerulosclerosis and granulomatous inflammation have both been associated with lymphoma. We report the case of a 56-year-old woman who initially developed focal and segmental glomerulosclerosis. After one year, the granulomatous inflammation was treated as tuberculosis infection and then as sarcoidosis. Finally, after another year, non-specified peripheral T-cell lymphoma was diagnosed.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.31847