Factors associated with the development of second primary tumours in head and neck cancer patients

Introduction The development of second primary tumours (SPTs) is one of the main causes of low survival in patients with head and neck cancer (HNC). The aim of this study was to review the evidence about factors associated with developing SPTs in patients with HNC. Methods An updated systematic revi...

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Published in:European journal of cancer care 2022-11, Vol.31 (6), p.e13699-n/a
Main Authors: Salcedo‐Bellido, Inmaculada, Requena, Pilar, Mateos, Rocío, Ortega‐Rico, Carmen, Olmedo‐Requena, Rocío, Lozano‐Lorca, Macarena, Arrebola, Juan Pedro, Barrios‐Rodríguez, Rocío
Format: Article
Language:English
Subjects:
Cancer
Case-Control Studies
Head & neck cancer
head and neck cancer
Head and Neck Neoplasms - complications
Human papillomavirus
Humans
Hypopharynx
Literature reviews
Meta-analysis
Neoplasms, Second Primary
Oropharynx
Pathogenesis
Patients
Quality assessment
Review
Reviews
second primary tumours
Smoking
Tobacco
Tumors
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Summary:Introduction The development of second primary tumours (SPTs) is one of the main causes of low survival in patients with head and neck cancer (HNC). The aim of this study was to review the evidence about factors associated with developing SPTs in patients with HNC. Methods An updated systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis guidelines, and the search was performed in Pubmed and Scopus. Only original articles with a cohort or case–control design were included. Article quality was assessed with the Newcastle–Ottawa scale. Results Thirty‐six and two case‐control studies were included, with quality medium (n = 5) to high (n = 33). Tobacco showed a significant association with SPT development, with risks ranging from 1.41 (95%CI: 1.04–1.91) to 5.52 (95%CI: 2.91–10.49). Regarding alcohol, risks ranged from 1.46 (95%CI: 1.12–1.91) to 21.3 (95%CI: 2.9–156). Location of the index tumour in the hypopharynx/oropharynx, absence of human papillomavirus and presence of a premalignant lesion also increased the risk of SPTs. More controversy was found for sex, age and other clinical factors of the tumour. Conclusion Toxic lifestyle habits and clinical factors were associated with the risk of SPTs in HNC patients. These findings may improve individualised prevention strategies in its follow‐up.
ISSN:0961-5423
1365-2354
DOI:10.1111/ecc.13699