Beta-Adrenergic Receptor Blockade Effects on Cardio-Pulmonary Exercise Testing in Healthy Young Adults: A Randomized, Placebo-Controlled Trial

Background Beta-blockers are increasingly prescribed while the effects of beta-adrenergic receptor blockade on cardio-pulmonary exercise test (CPET)-derived parameters remain under-studied. Methods Twenty-one young healthy adults repeated three CPET at the same time with an interval of 7 days betwee...

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Bibliographic Details
Published in:Sports medicine - open 2022-12, Vol.8 (1), p.150, Article 150
Main Authors: Forton, Kevin, Lamotte, Michel, Gillet, Alexis, Chaumont, Martin, van de Borne, Philippe, Faoro, Vitalie
Format: Article
Language:English
Subjects:
Adrenergic receptors
Medicine
Medicine & Public Health
Original
Original Research Article
Sports Medicine
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Summary:Background Beta-blockers are increasingly prescribed while the effects of beta-adrenergic receptor blockade on cardio-pulmonary exercise test (CPET)-derived parameters remain under-studied. Methods Twenty-one young healthy adults repeated three CPET at the same time with an interval of 7 days between each test. The tests were performed 3 h after a random, double-blind, cross-over single-dose intake of placebo, 2.5 mg or 5.0 mg bisoprolol, a cardio-selective beta1-adrenoreceptor antagonist. Gas exchange, heart rate (HR) and blood pressure (BP) were measured at rest and during cyclo-ergometric incremental CPET. Results Maximal workload and VO 2 max were unaffected by the treatment, with maximal respiratory exchange ratio > 1.15 in all tests. A beta-blocker dose-dependent effect reduced resting and maximal BP and HR and the chronotropic response to exercise, evaluated by the HR/VO 2 slope (placebo: 2.9 ± 0.4 beat/ml/kg; 2.5 mg bisoprolol: 2.4 ± 0.5 beat/ml/kg; 5.0 mg bisoprolol: 2.3 ± 0.4 beat/ml/kg, p  
ISSN:2199-1170
2198-9761
DOI:10.1186/s40798-022-00537-5