Low molecular weight cytotoxic components (DAMPs) form the post-COVID-19 syndrome

•The duration of post-COVID-19 symptoms is associated with neutrophil dysfunction and the formation of a specific humoral immunological pattern that performs an adaptive function and at the same time provides additional DAMPs production.•The DAMPs formed in the body of SARS-CoV-2 infection are not s...

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Published in:Immunobiology (1979) 2023-01, Vol.228 (1), p.152316-152316, Article 152316
Main Authors: Klimova, Elena M., Bozhkov, Anatoly I., Lavinska, Olena V., Drozdova, Larisa A., Kurhuzova, Nataliia I.
Format: Article
Language:English
Subjects:
Animals
Autoantibodies
C-Reactive Protein - metabolism
Complement C3
COVID-19
Cytotoxic components
Humans
Immune-metabolic state
Interleukin-18
Interleukin-6
Molecular Weight
Phagocytosis
Post-Acute COVID-19 Syndrome
post-COVID-19 syndrome
Rats
SARS-CoV-2
The complement system
Tumor Necrosis Factor-alpha
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Summary:•The duration of post-COVID-19 symptoms is associated with neutrophil dysfunction and the formation of a specific humoral immunological pattern that performs an adaptive function and at the same time provides additional DAMPs production.•The DAMPs formed in the body of SARS-CoV-2 infection are not species-specific.•The possibility of modeling post-COVID-19 manifestations in an experiment on rats is shown.•The preliminary administaration of the biologically active substance MF into the body “modifies” the subsequent adaptive response of the body to the actions of cytotoxic components of the patient's serum in such a way that the studied parameters are similar or close to the control values. We studied the role of cytotoxic components (DAMPs) formed in the body of patients with COVID-19 in ensuring the long-term preservation of post-COVID-19 manifestations and the possibility of creating an experimental model by transferring DAMPs to rats. In patients with post-COVID-19 syndrome (PCS) 2 months after SARS-CoV-2 infection we determined the presence of cytotoxic components in the blood serum (Terasaki test, Dunaliella viridis test and content of DAMPs). In post-COVID-19 syndrome patients with a high content of serum cytotoxic oligopeptide fraction (selective group, n = 16) we determined the number of leukocytes, lymphocytes, neutrophil granulocytes and monocytes in the blood, the content of C-reactive protein (CRP), the concentration of C3 and C4 complement components and circulating immune complexes, the serum content of IL-6, IL −10, IL-18, TNF-α, phagocytic activity of neutrophils, presence of neutrophil traps and autoantibodies ANA. It has been shown that in patients with PCS, there are components with cytotoxicity in the blood serum, form specific immunopathological patterns, which are characterized by: an increased content of CRP, complement system components C3 and C4 and cytokines (TNF-α, IL-6, IL-10, IL-18) activation, the formation of a wide range of autoantibodies ANA, the low efficiency of endocytosis in oxygen-independent phagocytosis; their phagocytic activity reaches its functional limit, and against this background, activation of neutrophil traps occurs, which can contribute to further induction of DAMPs. This self-sustaining cell-killing activation provided long-term preservation of PCS symptoms. The transfer of blood serum components from selective group patients with PCS to rats was accompanied by the appearance of cytotoxic components in the
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2022.152316