Vitamin B-6 and riboflavin, their metabolic interaction, and relationship with MTHFR genotype in adults aged 18–102 years

The generation of the active form of vitamin B-6, pyridoxal 5′-phosphate (PLP), in tissues is dependent upon riboflavin as flavin mononucleotide, but whether this interaction is important for maintaining vitamin B-6 status is unclear. To investigate vitamin B-6 and riboflavin status, their metabolic...

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Published in:	The American journal of clinical nutrition 2022-12, Vol.116 (6), p.1767-1778
Main Authors:	Jarrett, Harry, McNulty, Helene, Hughes, Catherine F, Pentieva, Kristina, Strain, J J, McCann, Adrian, McAnena, Liadhan, Cunningham, Conal, Molloy, Anne M, Flynn, Albert, Hopkins, Sinead M, Horigan, Geraldine, O’Connor, Ciara, Walton, Janette, McNulty, Breige A, Gibney, Michael J, Lamers, Yvonne, Ward, Mary
Format:	Article
Language:	eng
Subjects:	Adult Adults Aged Agriculture B-vitamin biomarkers Clinical trials Diet dietary intakes erythrocyte glutathione reductase activation coefficient Erythrocytes Flavin mononucleotide Flavin Mononucleotide - genetics Fortified foods Genotype Genotype & phenotype Genotypes Glutathione Glutathione reductase Human nutrition Humans Metabolism Methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) - genetics Methylenetetrahydrofolate Reductase (NADPH2) - metabolism MTHFR Nutrient status Nutrition surveys Older people Original Research Communications pyridoxal 5′-phosphate Pyridoxal Phosphate Pyridoxine Reductases Regression coefficients Riboflavin Surveys Trinity-Ulster Department of Agriculture (TUDA) Vitamin B Vitamin B 12 Vitamin B 6 Vitamins
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