Immune Profiling of Peripheral Blood Mononuclear Cells at Pancreas Acute Rejection Episodes in Kidney-Pancreas Transplant Recipients

Profiling of circulating immune cells provides valuable insight to the pathophysiology of acute rejection in organ transplantation. Herein we characterized the peripheral blood mononuclear cells in simultaneous kidney-pancreas transplant recipients. We conducted a retrospective analysis in a biopsy-...

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Published in:Transplant international 2022-11, Vol.35, p.10639-10639
Main Authors: Rovira, Jordi, Ramirez-Bajo, Maria Jose, Bañón-Maneus, Elisenda, Hierro-Garcia, Natalia, Lazo-Rodriguez, Marta, Piñeiro, Gaston J, Montagud-Marrahi, Enrique, Cucchiari, David, Revuelta, Ignacio, Cuatrecasas, Miriam, Campistol, Josep M, Ricart, Maria Jose, Diekmann, Fritz, Garcia-Criado, Angeles, Ventura-Aguiar, Pedro
Format: Article
Language:English
Subjects:
Health Archive
Humans
Kidney
Leukocytes, Mononuclear
Pancreas
Pancreas Transplantation
Retrospective Studies
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Summary:Profiling of circulating immune cells provides valuable insight to the pathophysiology of acute rejection in organ transplantation. Herein we characterized the peripheral blood mononuclear cells in simultaneous kidney-pancreas transplant recipients. We conducted a retrospective analysis in a biopsy-matched cohort ( = 67) and compared patients with biopsy proven acute rejection (BPAR; 41%) to those without rejection (No-AR). We observed that CD3+ T cells, both CD8+ and CD4+, as well as CD19+ B cells were increased in patients with BPAR, particularly in biopsies performed in the early post-transplant period (
ISSN:1432-2277
0934-0874
1432-2277
DOI:10.3389/ti.2022.10639