The road to physiological maturation of stem cell-derived cardiac muscle runs through the sarcomere

Recent advances the cardiac biomedical sciences have been propelled forward by the development and implementation of human iPSC-derived cardiac muscle. These notable successes notwithstanding, it is well recognized in the field that a major roadblock persists in the lack of full “adult cardiac muscl...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2022-09, Vol.170, p.117-120
Main Author: Metzger, Joseph M.
Format: Article
Language:English
Subjects:
hiPSC-CM
Maturation
Sarcomere
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Summary:Recent advances the cardiac biomedical sciences have been propelled forward by the development and implementation of human iPSC-derived cardiac muscle. These notable successes notwithstanding, it is well recognized in the field that a major roadblock persists in the lack of full “adult cardiac muscle-like” maturation of hiPSC-CMs. This Perspective centers focus on maturation roadblocks in the essential physiological unit of muscle, the sarcomere. Stalled sarcomere maturation must be addressed and overcome before this elegant experimental platform can reach the mountaintop of making impactful contributions in disease pathogenesis, drug discovery, and in clinical regenerative medicine.
ISSN:0022-2828
1095-8584
DOI:10.1016/j.yjmcc.2022.06.005