Effectiveness of Influenza Vaccination of Pregnant Women for Prevention of Maternal and Early Infant Influenza-Associated Hospitalizations in South Africa: A Prospective Test-Negative Study

Abstract Background Influenza vaccination during pregnancy reduces influenza-associated illness in the women and their infants, but effectiveness estimates against influenza-associated hospitalization are limited and lacking from settings with high human immunodeficiency virus (HIV) infection preval...

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Bibliographic Details
Published in:	Open forum infectious diseases 2022-11, Vol.9 (11), p.ofac552-ofac552
Main Authors:	Nunes, Marta C, Walaza, Sibongile, Meiring, Susan, Zar, Heather J, Reubenson, Gary, McMorrow, Meredith, Tempia, Stefano, Rossi, Liza, Itzikowitz, Raphaela, Bishop, Kate, Mathunjwa, Azwifarwi, Wise, Amy, Treurnicht, Florette K, Hellferscee, Orienka, Laubscher, Matt, Serafin, Natali, Cutland, Clare L, Madhi, Shabir A, Cohen, Cheryl
Format:	Article
Language:	eng
Subjects:	Analysis Children Diseases HIV (Viruses) Infants Influenza Influenza vaccines Major Medical research Medicine, Experimental Pharmaceutical industry Pregnant women Vaccination
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Summary:	Abstract Background Influenza vaccination during pregnancy reduces influenza-associated illness in the women and their infants, but effectiveness estimates against influenza-associated hospitalization are limited and lacking from settings with high human immunodeficiency virus (HIV) infection prevalence. We assessed the effect of maternal vaccination in HIV-uninfected women and women with HIV in preventing influenza-associated hospitalizations in infants and the women. Methods During 2015–2018, influenza vaccination campaigns targeting pregnant women were augmented at selected antenatal clinics; these were coupled with prospective hospital-based surveillance for acute respiratory or febrile illness in infants aged
ISSN:	2328-8957 2328-8957