Mobilizing the clinical trial ecosystem to drive adoption of master protocols

Master protocol studies typically use an overarching protocol to answer several questions by guiding a variety of sub-studies. These sub-studies can incorporate multiple diseases, therapies, or both. Although this innovative approach offers many benefits, including the ability to deliver clinical re...

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Bibliographic Details
Published in:Clinical trials (London, England) England), 2022-12, Vol.19 (6), p.690-696
Main Authors: Bronson, Abby, Chase, Marianne K, Fisher, Kimberly, Millar, Daniel, Perlmutter, Jane, Richardson, Nicholas
Format: Article
Language:English
Subjects:
Best practice
Clinical trials
Ecosystem
Humans
Medical research
Patients
Universities
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Summary:Master protocol studies typically use an overarching protocol to answer several questions by guiding a variety of sub-studies. These sub-studies can incorporate multiple diseases, therapies, or both. Although this innovative approach offers many benefits, including the ability to deliver clinical research that is more patient-centric and efficient, several common barriers curtail widespread adoption. The Clinical Trials Transformation Initiative (CTTI) convened industry representatives, regulatory agencies, patient groups, and academic institutions to identify emerging best practices and develop resources designed to help sponsors and other stakeholders overcome these challenges. We first identify some broad changes needed in the clinical trials ecosystem to facilitate mainstream adoption of master protocol studies, and we subsequently summarize CTTI’s resources designed to support this effort.
ISSN:1740-7745
1740-7753
DOI:10.1177/17407745221110199