Immune Status of Workers with Professional Risk of Being Affected by Chrysotile Asbestos in Kazakhstan

The purpose of this research was to study the particularities of the immune status of workers in the field of chrysotile asbestos production, depending on their work experience and professional risk of being affected by chrysotile dust. The research covered 125 men, who were workers at the only ente...

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Bibliographic Details
Published in:International journal of environmental research and public health 2022-11, Vol.19 (21), p.14603
Main Authors: Koigeldinova, Sholpan, Alexeyev, Alexey, Zharylkassyn, Zhengisbek, Otarov, Yertay, Omarkulov, Bauyrzhan, Tilemissov, Magzhan, Ismailov, Chingiz
Format: Article
Language:English
Subjects:
Aerosols
Age
Asbestos
Asbestos, Serpentine
Beneficiation
CD3 antigen
CD4 antigen
CD8 antigen
Cell-mediated immunity
Chrysotile
Clinics
Dust
Dust - analysis
Employees
Flow cytometry
Free radicals
Humans
Humoral immunity
Immune status
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Immunology
Kazakhstan
Leukocytes (neutrophilic)
Lymphocytes T
Male
Neutrophils
Occupational diseases
Occupational Exposure - analysis
Phagocytes
Womens health
Workers
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Summary:The purpose of this research was to study the particularities of the immune status of workers in the field of chrysotile asbestos production, depending on their work experience and professional risk of being affected by chrysotile dust. The research covered 125 men, who were workers at the only enterprise dealing with the extraction and beneficiation of chrysotile ores in Kazakhstan. Indicants of cell immunity were detected by flow cytometry; IgA, IgM, and IgG were detected by a multiplex immunological assay. It was found that, among workers impacted by chrysotile asbestos for more than 15 years, compared with individuals who were not impacted by asbestos dust, the level of CD3+ T-cells was decreased ( = -8.76, < 0.001), as well as the number of CD4+ T-cells (U = 1246.0, < 0.001). Moreover, CD8+ T-cells increased ( = 5.308, = 0.001), and neutrophil phagocytic activity also increased, by 1.2 times (U = 305.5, < 0.001). It was found that working under the condition of professional contact with chrysotile asbestos dust modifies the indicants of humoral immunity, IgA, IgM, and IgG, to a lesser extent than those of cellular immunity.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph192114603