Higher Dietary Inflammatory Index scores are associated with brain MRI markers of brain aging: Results from the Framingham Heart Study Offspring cohort

Introduction We investigated cross‐sectional associations between the Dietary Inflammatory Index (DII) and measures of brain volume and cerebral small vessel disease among participants of the Framingham Heart Study Offspring cohort. Methods A total of 1897 participants (mean ± standard deviation, ag...

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Bibliographic Details
Published in:Alzheimer's & dementia 2023-02, Vol.19 (2), p.621-631
Main Authors: Melo Van Lent, Debora, Gokingco, Hannah, Short, Meghan I., Yuan, Changzheng, Jacques, Paul F., Romero, José R., DeCarli, Charles S., Beiser, Alexa S., Seshadri, Sudha, Himali, Jayandra J., Jacob, Mini E.
Format: Article
Language:English
Subjects:
Aged
Aging
apolipoprotein E ε4
Brain - diagnostic imaging
Brain - pathology
brain volume
cerebral microbleeds
Cross-Sectional Studies
Framingham Heart Study
Humans
Inflammation
inflammatory diet
Longitudinal Studies
Magnetic Resonance Imaging - methods
Middle Aged
silent brain infarcts
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Summary:Introduction We investigated cross‐sectional associations between the Dietary Inflammatory Index (DII) and measures of brain volume and cerebral small vessel disease among participants of the Framingham Heart Study Offspring cohort. Methods A total of 1897 participants (mean ± standard deviation, age 62±9) completed Food Frequency Questionnaires and brain magnetic resonance imaging (MRI). Results Higher (pro‐inflammatory) DII scores, averaged across a maximum of three time points, were associated with smaller total brain volume (beta ± standard error: –0.16 ± 0.03; P < .0001) after adjustment for demographic, clinical, and lifestyle covariates. In addition, higher DII scores were associated with smaller total gray matter volume (–0.08 ± 0.03; P = .003) and larger lateral ventricular volume (0.04 ± 0.02; P = .03). No associations were observed with other brain MRI measures. Discussion Our findings showed associations between higher DII scores and global brain MRI measures. As we are one of the first groups to report on the associations between higher DII scores and brain volume, replication is needed to confirm our findings.
ISSN:1552-5260
1552-5279
1552-5279
DOI:10.1002/alz.12685