Bisphenol A: Potential Factor of Miscarriage in Women in the Context of the Phenomenon of Neutrophil Extracellular Traps

Humans are exposed to a number of environmental pollutants every day. Among them, endocrine disruptors are particularly harmful to human health. Bisphenol A (BPA) is a xenoestrogen that has been shown to disrupt the endocrine system and cause reproductive toxicity. In this study, we aimed to verify...

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Bibliographic Details
Published in:Archivum Immunologiae et Therapiae Experimentalis 2022, Vol.70 (1), p.24-24, Article 24
Main Authors: Omeljaniuk, Wioleta Justyna, Charkiewicz, Angelika Edyta, Garley, Marzena, Ratajczak-Wrona, Wioletta, Czerniecki, Jan, Jabłońska, Ewa, Cechowska-Pasko, Marzanna, Miltyk, Wojciech
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Bisphenol A
Endocrine disruptors
Endocrine system
Gas chromatography
Immunology
Inflammation
Leukocytes (neutrophilic)
Miscarriage
Monocyte chemoattractant protein 1
NAD(P)H oxidase
Neutrophils
Original
Original Article
Pharmacology/Toxicology
Pollutants
Pregnancy
Serum levels
Toxicity
Tumor necrosis factor-α
Xenoestrogens
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Summary:Humans are exposed to a number of environmental pollutants every day. Among them, endocrine disruptors are particularly harmful to human health. Bisphenol A (BPA) is a xenoestrogen that has been shown to disrupt the endocrine system and cause reproductive toxicity. In this study, we aimed to verify the potential relationship between BPA and miscarriage involving the formation of neutrophil extracellular traps (NETs). Blood samples were collected from healthy women and women who had miscarriage in the first trimester of pregnancy. The serum levels of cytoplasmic anti-PR3 antibody and perinuclear anti-MPO antibody were determined using an immunoenzymatic method. The concentrations of key proinflammatory proteins TNF-α and MCP-1, as well as NADPH oxidase subunits NOX1 and NCF2, were also measured in the serum samples. The serum concentration of BPA was determined using gas chromatography. The results showed that the concentrations of BPA were significantly elevated in the serum of women who had miscarriage compared to the control group, with the highest concentration found in the “NETs-positive” group. The levels of MCP-1 and TNF-α were significantly higher in the “NETs-positive” group compared to the “NETs-negative” and control group. The levels of NOX1 and NCF2 were also higher in the “NETs-positive” group compared to the “NETs-negative” group. The study showed that BPA could play a role in the course of miscarriage through the formation of NETs. The results indicate the need to limit the exposure of women planning pregnancy to xenoestrogens, including BPA.
ISSN:0004-069X
1661-4917
DOI:10.1007/s00005-022-00661-w